Regulatory Forum Opinion Piece: Carcinogen Risk Assessment

Carcinogen risk assessment.

A molecular biological rationale for the linear nonthreshold dose-response pattern for carcinogenesis is presented based on the mutagenic activation of oncogens as the basis of initiation. The approach assumes that the linear nonthreshold dose pattern at very low doses applies only to tissues that are promoted by intrinsic and extrinsic agents other than the one being modeled, and that risk is ...

Regulatory forum opinion piece: the role of the toxicologic pathologist in the postgenomic era: challenges and opportunities.

The "omics," high-throughput screening, computational modeling, and database mining revolutions have each arrived with euphoric expectations, considerable hand waving, and promises to set toxicity testing priorities and reduce reliance on conventional animal toxicity and carcinogenicity testing. Reflecting back on prior experience with other predictive approaches and alternatives, what follows ...

Guidelines for Carcinogen Risk Assessment

Guidelines for Carcinogen Risk Assessment

ISM Science Corner - Opinion Piece

By now many Canadians know that February is heart month, thanks to annual canvassing of the Heart and Stroke Foundation of Canada. February, it turns out, is the peak month for heart attacks, but did you ever wonder why? If you subscribe to the notion that high cholesterol is the main or major risk factor for heart attacks, then you would be surprised to know that seasonal differences in choles...